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PRP – Scientific Background

What is Platelet-Rich Plasma?

Platelet-Rich Plasma (PRP) is an innovative and promising approach in tissue regeneration. PRP is defined as an autologous concentrated preparation of platelets and their associated growth factors in a small volume of plasma [1]. Platelets are a natural source of numerous growth factors in their natural and biologically-determined ratios.

 

Therapeutic Effect of PRP

PRP is thought to promote physiological wound healing and rapid soft and hard tissue regeneration by delivering growth factors at high concentrations to the treated site.

 

Platelet Growth Factors

Upon activation, platelets release growth factors and other molecules stored in their α granules, which are part of the natural healing process. These growth factors are regeneration-promoting signaling molecules, such as Platelet-Derived Growth Factor (PDGF), Transforming Growth Factor group (TGF), Epidermal Growth Factor (EGF), Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factor (FGF) and others. These molecules regulate the healing cascade, including inflammation, cell proliferation, reepithelialization, angiogenesis and tissue remodeling processes.

 

Platelet Activation

Platelets may be activated via addition of activating substances such as thrombin and calcium chloride. However, It has been postulated that in situ activation of platelets (caused by injection and exposure to in situ coagulation factors, such as collagen, exposed endothelium) results in a slow release pattern of growth factors secretion, which may be beneficial for stimulating a continuous healing response.

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